ChloroquineV1, Main, Exploration, bibRecord, 002E15

Morphometric analysis of the effect of chloroquine on rat foetal lung maturation

Identifieur interne : 002E15 ( Main/Exploration ); précédent : 002E14; suivant : 002E16

Morphometric analysis of the effect of chloroquine on rat foetal lung maturation

Auteurs : A. O. Okanlawon [Nigeria] ; A. B. Ejiwunmi ; M. O. Dada ; O. A. Ashiru

Source :

East African medical journal [ 0012-835X ] ; 1993.

RBID : Pascal:93-0588200

Descripteurs français

KwdFr :
- Animaux, Antipaludiques (effets indésirables), Chloroquine (analogues et dérivés), Chloroquine (effets indésirables), Femelle, Grossesse, Maturité foetale, Poumon (), Poumon (anatomie et histologie), Poumon (embryologie), Rat Sprague-Dawley, Rats, Taille d'organe, Évaluation préclinique de médicament.
MESH :
- analogues et dérivés : Chloroquine.
- anatomie et histologie : Poumon.
- effets indésirables : Antipaludiques, Chloroquine.
- embryologie : Poumon.
Pascal (Inist)
- Animaux, Chloroquine, Femelle, Grossesse, Maturation, Maturité foetale, Poumon, Rat Sprague-Dawley, Rats, Taille d'organe, Toxicité, Poumon, Foetus, Animal, Chimiothérapie, Rat, Évaluation préclinique de médicament.

English descriptors

KwdEn :
- Animal, Animals, Antimalarials (adverse effects), Chemotherapy, Chloroquine (adverse effects), Chloroquine (analogs & derivatives), Drug Evaluation, Preclinical, Female, Fetal Organ Maturity, Fetus, Lung, Lung (anatomy & histology), Lung (drug effects), Lung (embryology), Organ Size, Pregnancy, Rat, Rats, Rats, Sprague-Dawley, Ripening, Toxicity.
MESH :
- chemical , adverse effects : Antimalarials, Chloroquine.
- chemical , analogs & derivatives : Chloroquine.
- anatomy & histology : Lung.
- drug effects : Lung.
- embryology : Lung.
- Animals, Drug Evaluation, Preclinical, Female, Fetal Organ Maturity, Organ Size, Pregnancy, Rats, Rats, Sprague-Dawley.

Abstract

Pregnant Sprague-Dawley rats were injected with chloroquine phosphate (40mg/kg b. wt 1.p) in the late canalicular (day 20) and early terminal-sac (day 21) and sacrificed in the late terminal sac (day 22=term) stage of foetal lung development. The control animal received normal saline. Morphometric evaluation of the lungs by light microscopy revealed three important exposure - related lesions. They were: (a) reduction in the volume density of parenchyma and saccular space, (b) reduction in the volume of an average saccule and, (c) an increase in the number of saccules per unit volume (Numerical Density)

Affiliations:

Nigeria

Le document en format XML

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<term>Chloroquine (analogs & derivatives)</term>
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<term>Chloroquine (effets indésirables)</term>
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<front><div type="abstract" xml:lang="en">Pregnant Sprague-Dawley rats were injected with chloroquine phosphate (40mg/kg b. wt 1.p) in the late canalicular (day 20) and early terminal-sac (day 21) and sacrificed in the late terminal sac (day 22=term) stage of foetal lung development. The control animal received normal saline. Morphometric evaluation of the lungs by light microscopy revealed three important exposure - related lesions. They were: (a) reduction in the volume density of parenchyma and saccular space, (b) reduction in the volume of an average saccule and, (c) an increase in the number of saccules per unit volume (Numerical Density)</div>
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Serveur d'exploration Chloroquine

Morphometric analysis of the effect of chloroquine on rat foetal lung maturation

Morphometric analysis of the effect of chloroquine on rat foetal lung maturation

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

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